RESUMO
It is estimated that colorectal cancer is the cancer disease with the highest incidence in Spainâ due to the increase in life expectancy and changes in the lifestyle of the populationâ. Early detection through disease screening programs allows for more effective treatment and a higher survival rateâ. Advances in treatment have been made, such as targeted therapies, which focus on specifically attacking cancer cells and preventing their growthâ. However, much remains to be done in terms of prevention and treatment of colorectal cancer. More research and medical advances are required to combat this disease.
Se estima que el cáncer colorrectal es la enfermedad oncológica que presenta mayor incidencia en Españaâ debido al incremento en la esperanza de vida y a los cambios en el estilo de vida de la poblaciónâ. La detección precoz mediante los programas de cribado de la enfermedad permite un tratamiento más efectivo y una mayor tasa de supervivenciaâ. Se han realizado avances en el tratamiento, como las terapias dirigidas, que se centran en atacar específicamente a las células cancerosas y prevenir su crecimientoâ. Sin embargo, todavía queda mucho por hacer en términos de prevención y tratamiento del cáncer colorrectal. Se requiere más investigación y más avances médicos para combatir esta enfermedad.
Assuntos
Neoplasias Colorretais , Pacientes , Humanos , Espanha , Expectativa de Vida , Estilo de Vida , Neoplasias Colorretais/diagnóstico , Neoplasias Colorretais/terapiaRESUMO
BACKGROUND: The outcomes of liver resection (LR) with a narrow margin in patients with transplantable hepatocellular carcinoma (HCC) have not been studied. The aim was to assess whether narrow margin following up-front LR impacts the incidence, timing, pattern, and transplantability of tumor recurrence in patients with initially transplantable HCC. METHODS: All initially transplantable HCC patients undergoing hepatectomy with either narrow (<10 mm) or wide (≥10 mm) margins from 2007 to 2016 at four Western university centers were compared in terms of recurrence, transplantability of recurrence, recurrence-free survival (RFS), and intention-to-treat overall survival (ITT-OS). Independent predictors of non-transplantability of recurrence were assessed. RESULTS: This study included 187 patients (narrow group, n = 107 vs. wide group, n = 80). Recurrence was significantly more frequent in the narrow margin group (44% vs. 26%; p = 0.01) with a shorter RFS (p = 0.03). The transplantability of recurrence and ITT-OS were, however, not different between the two groups. The presence of satellite nodules on the resected specimens emerged as the sole independent predictor of non-transplantability of tumor recurrence. The stratification of the analysis according to the presence of cirrhosis achieved essentially the same results as in the whole study population. CONCLUSIONS: Narrow margin was associated with a higher tumor recurrence rate and a shorter RFS for patients with initially transplantable HCC. However, transplantability of recurrence and long-term ITT-OS were not impaired.